Quantitative evaluation of gentamicin induced structural alterations and degree of functional. Gentamicin, cimetidine, losartan, vitamin e, rats, nephrotoxicity. We also investigated the effects of mt on induction of apoptotic cell death and its potential mechanisms in renal tissues in response to gm treatment. The effect of isosorbide diuresis on gentamicin excretion and tissue accumulation as well as gentamicin induced histopathologic changes in renal tissue were examined in rats. Gentamicin, at doses of 50 or 100 mgkg body wt administered daily to healthy male mf1 mice by i. Ethanolic extract of garlic for attenuation of gentamicininduced nephrotoxicity in wistar rats hamid nasri,1 mehdi nematbakhsh,1 mahmoud rafieiankopaei2 introduction. This study demonstrates an improvement in renal function in response to the administration of tr in gentamicininduced nephrotoxicity. Protective effect of quercetin against gentamicin induced nephrotoxicity in rats. The plant extract of rhazya stricta has been noted to dosedependently increase the superoxide dismutase activity and the reducedform of glutathione and subsequently decrease lipid peroxides in the renal cortex of gentamicin administered rats.
This prompted a surge in research into the possible influences of certain agents that can ameliorate. Renal protective effect of hesperidin on gentamicininduced acute. Hyperbaric oxygen treatment and nephrotoxicity induced by. Aminoglycosideinduced nephrotoxicity article pdf available in journal of pharmacy practice 276 september 2014 with 1,253 reads how we measure reads. This article is from iranian journal of basic medical sciences, volume 16. Environmental issues aminoglycosides antioxidants antioxidants nutrients cinnamon health aspects laboratory rats materia medica, vegetable plant extracts rats as laboratory animals toxicity research urea. The aim of the present study was to evaluate the protective effect of crocin against gentamicininduced nephrotoxicity in rats. Gentamicininduced nephrotoxicity in rats ameliorated and healing effects of resveratrol. Effect of nacetylcysteine on gentamicinmediated nephropathy in. Experimental gentamicin nephrotoxicity and agents that modify it. A number of crude herbal extracts have been reported to ameliorate gentamicin induced nephrotoxicity. We studied gentamicin susceptibility of kidneys infected with e. Protective effect of nebivolol on gentamicininduced nephrotoxicity in rats article pdf available in bratislavske lekarske listy 11911.
Renal protective effect of hesperidin on gentamicin. Effects of hydration on gentamicin excretion and renal accumulation in furosemidetreated rats. Comparative study on gentamicin and streptomycin induced. Multiple factors may increase the nephrotoxic potential of aminoglycosides. Thirtyfive spraguedawley rats were divided into 5 groups to receive saline. Nephrotoxicity is a serious side effect of gentamicin and is believed. The present study was undertaken to evaluate the aqueous extract of k. Attenuation of gentamicininduced nephrotoxicity in rats by. Research article sildenafil ameliorates gentamicininduced.
Influence of spironolactone treatment on gentamicin. Inhibitory effects of cinnamon extract on gentamicininduced nephrotoxicity in mail adult wistar rats. Sep 07, 2014 aminoglycosideinduced nephrotoxicity article pdf available in journal of pharmacy practice 276 september 2014 with 1,253 reads how we measure reads. Several parameters of renal function, histological changes on light and electron microscopy, and drug levels in renal parenchyma were com. Some antioxidant agents that have been used to ameliorate gentamicin induced nephrotoxicity in rats. Inhibitory effects of cinnamon extract on gentamicin. Protective effect of transresveratrol on gentamicin. Monitor renal and auditory function during therapy and discontinue therapy or adjust. Effect of ethanolic and aqueous extracts of bauhinia. Diagnosis and treatment aminoglycoside nephrotoxicity typically is associated with nonoliguric acute renal failure, that is, azotemia in the presence. Gentamicin is an important aminoglycoside antibiotic that is commonly used in serious and life. Osmotic diuresis with isosorbide did not significantly reduce the dosedependent extent of. Nephrotoxicity was induced in rats by injecting gentamicin intramuscularly i. Rats were treated with curcumin 100 mgkg body mass by intragastric administration, once daily, followed with an intraperitoneal injection of gentamicin sulfate solution at a dose of 80 mgkg body mass for 8 consecutive days.
Gentamicininduced aki was established in female spraguedawley rats. Vitamin bcomplex dosedependently ameliorated gentamicin induced nephrotoxicity in adult swiss albino rats when given intramuscularly. The aim of this study was to evaluate the effect of subacute administration of propylthiouracil ptu on gentamicin gminduced nephrotoxicity in male rats. Antioxidants, gentamicin, hesperidin, nephrotoxicity, oxidative stress. Animals were injected during 4 or 10 days with saline nacl.
Research article open access hyperbaric oxygen treatment and nephrotoxicity induced by gentamicin in rats matitiahu berkovitch1,2, yossi shain1,2, eran kozer1,2, michael goldman1,2 and ibrahim abukishk1,2 abstract background. The present study was designed to determine the protective effect of salicylic acid sa in gentamicininduced nephrotoxicity in rats. The present results indicate that spironolactone aggravates gentamicin. Finally, gentamicin nephrotoxicity is potentiated by magnesium depletion 27. Role of dl alphalipoic acid in gentamicin induced nephrotoxicity. Study on the effect of ethanol extract of ipomoea aquatica.
Inhibitory effect of olive leaf extract on gentamicininduced. Molecular mechanism of drug induced nephrotoxicity 1. Apr 12, 2012 the present study investigated the protective effects of melatonin mt against gentamicin gm induced nephrotoxicity and oxidative stress in rats. Pioglitazone attenuates kidney injury in an experimental. Animal care was in compliance with the guidelines of the animal and. Due to high relative blood flow the kidney is prone to druginduced damage. Materials and methods forty eight female rats were divided into 6 groups n8 as follows. Gentamicin induced acute renal failure model a variety of exogenous mainly drugs or endogenous toxins cause acute kidney injury aki in humans and in experimental animals. Effect of dimethyl sulfoxide on gentamicin induced nephrotoxicity in rats. M in gml for the various invitro antioxidant models was determined by regression analysis. Effect of dimethyl sulfoxide on gentamicininduced nephrotoxicity in rats. For this purpose female spraguedawley rats were given intraperitoneally either gentamicin sulphate 40 mgkg, melatonin 10 mgkg, gentamicin plus melatonin or vehicle control twice.
The aim of this study was to evaluate the effect of subacute administration of propylthiouracil ptu on gentamicin gm induced nephrotoxicity in male rats. Gentamicin induced nephrotoxicity is a model of acute renal failure caused by oxidative stress generated through the induction of superoxide anions. Pinocembrin attenuates gentamicininduced nephrotoxicity. Department of biochemistry, faculty of pharmacy, october 6 th university, october 6 th city, egypt keywords. Gentamicin gnt is an aminoglycoside antibiotic used for treatment of serious infections, and the nephrotoxic adverse effect is one of the main therapeutic limitations. Injection route solution therapy has been associated with potential neurotoxicity, ototoxicity, and nephrotoxicity. Effect of cimetidine on gentamicinlosartan induced. Apr 18, 2019 aminoglycoside induced ototoxicity is usually irreversible. Flavocoxid attenuates gentamicininduced nephrotoxicity in rats. Inhibitor of extracellular cysteine proteinase widely expressed by nucleated cells increased in. Gentamicin gm induced nephrotoxicity may be sex hormones related. Inhibitory effect of olive leaf extract on gentamicin.
The protective effect of apo might be due to the reduction of the free. Renal protective effect of hesperidin on gentamicininduced acute nephrotoxicity in male wistar albino rats. Gentamicin, bcomplex, swiss albino rats, nephrotoxicity, serum urea and creatine. Rats subjected to gentamicin induced nephrotoxicity, treated with pioglitazone at dose of 0. Inhibitory effects of cinnamon extract on gentamicininduced. Hyperbaric oxygen treatment and nephrotoxicity induced by gentamicin in rats matitiahu berkovitch1,2, yossi shain1,2, eran kozer1,2, michael goldman1,2 and ibrahim abukishk1,2 abstract background. However, gentamicin administration is limited because of nephrotoxicity. Cimetidine appears to have protective effect on gentamicin losartan induced nephrotoxicity in rats. The effect of isosorbide diuresis on gentamicin excretion and tissue accumulation as well as gentamicininduced histopathologic changes in renal tissue were examined in rats. Aug 08, 2016 nephrotoxicity was induced in rats by intraperitoneal injection i. Gentamicininduced acute renal failure model creative biolabs.
Osmotic diuresis with isosorbide did not significantly reduce. Gentamicin induced acute renal damage and its evaluation using. They were injected with gentamicin sulfate 100 mg kg. Although the exact mechanism of gentamicininduced nephrotoxicity is not well. Introduction gentamicin is an e ective aminoglycoside antibiotic against serious gramnegative bacterial infections. Although the rates of aki we observed are similar to other reported rates of gentamicin nephrotoxicity, 1,2,5,1012 it is clear that these rates are higher than in some studies, which in part may be due to differing definitions of nephrotoxicity. Protective effect of crocin on gentamicininduced nephrotoxicity in rats. Effect of normobaric hyperoxia on gentamicininduced. Gentamicin induced nephrotoxicity in sprague dawley rats is. The aim of the study was to investigate the renoprotective effect of hesperidin hdn, a citrus. Comparative study on gentamicin and streptomycin induced nephrotoxicity in rats world small animal veterinary association world congress proceedings, 2004 m. Quantitative evaluation of gentamicininduced structural alterations and degree of functional.
Gentamicininduced nephrotoxicity is a model of acute renal failure caused by oxidative stress generated through the induction of superoxide anions. Gentamicininduced acute renal failure model creative. The activities of lactate dehydrogenase and alkaline phosphatase were higher in rats treated with gentamicin than in control rats and were reduced by the treatment with tr. The effect of fleroxacin on gentamicininduced nephrotoxicity was evaluated with. Ethanolic extract of garlic for attenuation of gentamicin. Protective effect of pongamia pinnata flowers against cisplatin and gentamicin induced nephrotoxicity in rats annie shirwaikarl, s malini2, s chandrika kumari i i department of pharmacognosy, college of pharm.
Effect of nacetylcysteine on gentamicin mediated nephropathy in. Wistar albino rats of either sex were divided into four groups. Gentamicin gnt is an aminoglycoside antibiotic used for treatment of serious. The present study investigated the protective effects of melatonin mt against gentamicin gminduced nephrotoxicity and oxidative stress in rats. Administration of nigella sativa extract prevented gentamicininduced nephrotoxicity in rats by reducing renal oxidative stress and enhancing antioxidant defense mechanism. Renal protective effect of hesperidin on gentamicininduced. In this study we investigated the role of free radicals in gentamicin. In recent years gentamicin nephrotoxicity is significantly reduced by shifting to once daily dosage as well as by eliminating known risk factors. Nephrotoxicity, gentamicin, astaxanthin, oxidative stress. Gentamicin induced nephrotoxicity in rats albino rats 150200 g of either sex were used for the study. Pioglitazone attenuates kidney injury in an experimental model of. Gentamicin 30, 60, 120, 160 mgkg was administered s.
Protective effect of pongamia pinnata flowers against. Nephrotoxicity was induced in rats by intraperitoneal injection i. Environmental issues aminoglycosides antioxidants antioxidants nutrients cinnamon health aspects laboratory rats materia medica, vegetable plant extracts rats as laboratory animals. In other hand, gentamicin reduces efficiency in kidney antioxidant enzymes like superoxide dismutase sod, catalase cat, glutathione peroxidase gpx and glutathione gsh 7. This study aimed to investigate the possible protective effect of apocynin apo on nephrotoxicity induced by gnt in rats. Pdf protective effect of crocin on gentamicininduced. Gentamicin 80 mg 1 kg 1 day for 6 days, intramuscularly produced the typical pattern of nephrotoxicity. Serum concentrations of aminoglycosides should be monitored when feasible to assure adequate levels and to avoid potentially toxic levels. Nephrotoxicity is a significant adverse side effect of gentamicin. Aminoglycoside nephrotoxicity kidney international. Original article, report by advances in environmental biology. The effect of fleroxacin on gentamicin induced nephrotoxicity was evaluated with female spraguedawley rats.
The effect of fleroxacin on gentamicininduced nephrotoxicity was evaluated with female spraguedawley rats. Gentamicin gnt is an aminoglycoside antibiotic used for the treatment of serious grampositive and gramnegative bacterial infections. Gentamicin induced nephrotoxicity was indicated by the reduced renal function and renal oat3 function and expression. Aminoglycoside type antibiotic gentamicin is one of the leading cause of druginduced nephrotoxicity. Thirtysix adult wistar albino rats were divided into six equal groups. Cimetidine appears to have protective effect on gentamicinlosartaninduced nephrotoxicity in rats.
Nephrotoxicity was induced in wistar rats by intraperitoneal administration of gentamicin 100 mgkgday for eight days. Thus, this property of drugstoxin is utilized by investigators to induce disease models for clinical research of potential drugs as well as to study the pathogenesis of. The effect of manganese chloride on gentamicininduced. Research article renal protective effect of hesperidin on. The present study was designed to determine the protective effect of salicylic acid sa in gentamicin induced nephrotoxicity in rats. Group3 and 4 received eeot 250 and 500 mgkgd, for 21 days orally plus gentamicin simultaneously. Gentamicin gm is a widely used antibiotic against serious and lifethreatening infections, but its usefulness is limited by the development of nephrotoxicity. However, there are still controversies and speculation about the precise mechanism of action. Gentamicininduced acute renal failure model a variety of exogenous mainly drugs or endogenous toxins cause acute kidney injury aki in humans and in experimental animals. Mar 24, 2017 gentamicin induced nephrotoxicity has been extensively studied in the past and has become one of the established models of drug induced nephrotoxicity. Renal protective effect of hesperidin on gentamicin induced acute nephrotoxicity in male wistar albino rats. Increased nephrotoxicity of gentamicin in pyelonephritic rats. Concurrent use of other potentially neurotoxic or nephrotoxic agents, or potent diuretics should be avoided. Pdf protective effect of nebivolol on gentamicininduced.
This work examines the influence of age on some nephrotoxic signs of gentamicin in normal and diabetic rats aged 1 and 24 months. The aim of this study was to investigate the effects of manganese chloride on gentamicininduced nephrotoxicity in rats. Pdf in this study, we aimed to investigate the possible protective effect of resveratrol on. Figure 2b and sod figure 2c activities in rat kidney homogenate.
Effects of cosupplementation of vitamins e and c on. Pdf influence of iron, deferoxamine and ascorbic acid on. Protective effects of curcumin on acute gentamicininduced. However, its usefulness is limited by nephrotoxicity, which may occur in 30% of treated patients mathew 1992. Pinocembrin attenuates gentamicininduced nephrotoxicity in.
Diagnosis and treatment aminoglycoside nephrotoxicity typically is associated with nonoliguric acute renal. Vitamin bcomplex dosedependently ameliorated gentamicininduced nephrotoxicity in adult swiss albino rats when given intramuscularly. The effects of sex hormones on gm induced nephrotoxicity in gonadectomized rats were investigated. Gentamicininduced apoptosis in renal cell lines and embryonic rat fibroblasts. Salicylic acid attenuates gentamicininduced nephrotoxicity. Methods subjects male spraguedawley rats weighing 200300 g were housed under controlled environmental conditions 24 2 c and 12 h lightdark cycle and allowed free access to standard rat chow and tap water. Patients with impaired renal function, advanced age, dehydration, and those who receive high doses or prolonged therapy are at an increased risk of toxicity. Additionally, gentamicin induced tubular necrosis in rats kidneys, increased concentration of kim1 and ngal as well as parameters of renal. Melatonin attenuates gentamicininduced nephrotoxicity and. Does propylthiouracil increase the gentamicininduced. Protective effect of apocynin against gentamicininduced.
Group2 received gentamicin gm 80 mgkgd, for 8 days intraperitoneally. Introduction gentamicin is an aminoglycoside antibiotic widely used for the treatment of bacterial infections. Pdf gentamicininduced nephrotoxicity in rats ameliorated and. Treated animals demonstrated a typical pattern of nephrotoxicity characterized by increased serum creatinine and urea. Gentamicininduced nephrotoxicity was indicated by the reduced renal function and renal oat3 function and expression. Pdf protective effect of quercetin against gentamicin. Taken together, pharmacological interventions like antioxidants, ros scavengers and antioxidant enzymes are able to prevent gentamicininduced nephrotoxicity. Attenuation of gentamicininduced nephrotoxicity in rats. Hdn supplementation to geninduced rats significantly decreased serum urea, uric acid.
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